Simulations in Physiology: The Respiratory System

Producer: PERC (Physiology Educational Research Consortium)

A series of 11 simulated clinical and laboratory situations, each dealing with a limited number of concepts relevant to the physiology of the respiratory system and comparing data from up to 7 ‘experiments’. Four general areas of study are included, and the simulations in each of them build in complexity. There are 4 mechanics models - Static relationships (elastic properties of the lung, chest wall, and total respiratory system), Dynamic relationships I (effects of lung compliance and airway resistance on tidal volume development), Work of breathing (oxygen cost of elastic, resistive, and total work during inspiration), Dynamic relationships II (respiratory dynamics of the total respiratory system); 3 general gas exchange models - Alveolar gas exchange, O2 and CO2 dissociation curves, Exchange from atmosphere to tissues (influence of alveolar ventilation, cardiac output, and anatomic shunt flow on arterial blood composition and gas exchange at the tissues); 3 VA/Q relationships models - Gas exchange in a single alveolus (effects of ventilation-perfusion ratio and inspired gas composition on exchange in a single exchange unit), The non-uniform lung (gas exchange from atmosphere to tissues with VA/Q mismatching in the lung),  Overall gas exchange (gas exchange from atmosphere to tissues with VA/Q mismatching and a true shunt), and one acid-base balance model - Acid-base balance (from a base excess viewpoint).


Medium: Downloadable fromwebsite
System requirements: Compatible with Windows or Windows Emulator
Price: Freeware